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Stem rust resistance in wheat is suppressed by a subunit of the mediator complex

Author: Hiebert, C. W.
Author: Moscou, M.J.
Author: Hewitt, T.
Author: Steuernagel, B.
Author: Hernández-Pinzón, I.
Author: Green, P.
Author: Pujol, V.
Author: Peng Zhang
Author: Rouse, M.N.
Author: Yue Jin
Author: McIntosh, R.
Author: Upadhyay, N
Author: Jianping Zhang
Author: Bhavani, S.
Author: Vrána, J.
Author: Karafiátová, M.
Author: Li Huang
Author: Fetch, T.G.
Author: Dolezel, J.
Author: Wulff, B.B.H
Author: Lagudah, E.S.
Author: Spielmeyer, W.
Year: 2020
ISSN: 2041-1723 (Print)
URI: https://hdl.handle.net/10883/20798
Format: PDF
Language: English
Publisher: Nature Publishing Group
Copyright: CIMMYT manages Intellectual Assets as International Public Goods. The user is free to download, print, store and share this work. In case you want to translate or create any other derivative work and share or distribute such translation/derivative work, please contact CIMMYT-Knowledge-Center@cgiar.org indicating the work you want to use and the kind of use you intend; CIMMYT will contact you with the suitable license for that purpose.
Type: Article
Place of Publication: London (United Kingdom)
Issue: 1
Issue: art. 1123
Volume: 11
DOI: 10.1038/s41467-020-14937-2
Description: Stem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar ‘Canthatch’ suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-sorted chromosomes, mutagenesis, and map-based cloning. The gene encodes Med15, a subunit of the Mediator Complex, a conserved protein complex in eukaryotes that regulates expression of protein-coding genes. Nonsense mutations in Med15b.D result in expression of stem rust resistance. Time-course RNAseq analysis show a significant reduction or complete loss of differential gene expression at 24 h post inoculation in med15b.D mutants, suggesting that transcriptional reprogramming at this time point is not required for immunity to stem rust. Suppression is a common phenomenon and this study provides novel insight into suppression of rust resistance in wheat.
Agrovoc: WHEAT
Agrovoc: DISEASE RESISTANCE
Agrovoc: RUSTS
Agrovoc: GENETIC RESISTANCE
Notes: The dataset related with this article is only referential
Related Datasets: https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-14937-2/MediaObjects/41467_2020_14937_MOESM1_ESM.pdf
Journal: Nature Communications


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  • Wheat
    Wheat - breeding, phytopathology, physiology, quality, biotech

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