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Stem rust resistance in wheat is suppressed by a subunit of the mediator complex

Author: Hiebert, C. W.
Author: Moscou, M.J.
Author: Hewitt, T.
Author: Steuernagel, B.
Author: Hernández-Pinzón, I.
Author: Green, P.
Author: Pujol, V.
Author: Peng Zhang
Author: Rouse, M.N.
Author: Yue Jin
Author: McIntosh, R.
Author: Upadhyay, N
Author: Jianping Zhang
Author: Bhavani, S.
Author: Vrána, J.
Author: Karafiátová, M.
Author: Li Huang
Author: Fetch, T.G.
Author: Dolezel, J.
Author: Wulff, B.B.H
Author: Lagudah, E.S.
Author: Spielmeyer, W.
Year: 2020
ISSN: 2041-1723 (Print)
Format: PDF
Language: English
Publisher: Nature Publishing Group
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Type: Article
Place of Publication: London (United Kingdom)
Issue: 1
Issue: art. 1123
Volume: 11
DOI: 10.1038/s41467-020-14937-2
Description: Stem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar ‘Canthatch’ suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-sorted chromosomes, mutagenesis, and map-based cloning. The gene encodes Med15, a subunit of the Mediator Complex, a conserved protein complex in eukaryotes that regulates expression of protein-coding genes. Nonsense mutations in Med15b.D result in expression of stem rust resistance. Time-course RNAseq analysis show a significant reduction or complete loss of differential gene expression at 24 h post inoculation in med15b.D mutants, suggesting that transcriptional reprogramming at this time point is not required for immunity to stem rust. Suppression is a common phenomenon and this study provides novel insight into suppression of rust resistance in wheat.
Agrovoc: WHEAT
Agrovoc: RUSTS
Notes: The dataset related with this article is only referential
Related Datasets:
Journal: Nature Communications

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  • Wheat
    Wheat - breeding, phytopathology, physiology, quality, biotech

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