||Maize is a widely grown cereal after rice and wheat and contributes almost 5% to the global dietary supply. In the Eastern Gangetic Plains (EGP) including India, Bangladesh, and Nepal, maize is an emerging cash crop, because of its high yield potentiality and also the favorable climatic conditions which allow maize production round the year. In Bangladesh, area and production of maize are escalating due to the increasing demand for poultry, livestock, and fish feed, and fodder for animals and starch industries in the region. Presently, more than 90% of maize is planted by manual dibbling following 5–6 intensive tillage, which increases the cost of cultivation. The conservation agricultural (CA)-based new agricultural practices could overcome those above challenges. CA is cost-effective and environmentally friendly; however, weeds are one of the key challenges in the system. The chapter described the uses of herbicides in different ways of combinations to make effective weed control in CA-based maize to achieve potential production and profits by reducing the intensive pressure of manual weeding. The efficient and right use of pre-plant/sowing, pre- and post-emergence herbicides and their combination may be the best way for effective control of weeds in maize production.