Climate change is leading to increased occurrence of and yield losses to wheat diseases. Managing these diseases by introducing new, effective and diverse resistance genes into cultivars represents an important component of sustainable wheat production. In 2016 and 2017 a set of primary hexaploid synthetic wheat was studied under high disease pressure: powdery mildew, leaf and stem rust in Omsk; Septoria tritici and S. nodorum in Moscow. A total of 28 synthetics (19 CIMMYT synthetics and 9 Japanese synthetics) were selected as having combined resistance to at least two diseases in both years of testing. Two synthetics (entries 13 and 18) originating from crosses between winter durum wheat Ukrainka odesskaya-1530.94 and various Aegilopes taushii accessions, and four synthetics (entries 20, 21, 23 and 24) from cross between Canadian durum wheat Langdon and Ae. taushii were resistant to all four pathogens. Pathological and molecular markers evaluation of resistance suggests presence of new genes and diverse types of resistance. The novel genetic sources of disease resistance identified in this study can be successfully utilized in wheat breeding.