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Genetic dissection of grain zinc concentration in spring wheat for mainstreaming biofortification in CIMMYT wheat breeding

Author: Velu, G.
Author: Singh, R.P.
Author: Crespo Herrera, L.A.
Author: Juliana, P.
Author: Dreisigacker, S.
Author: Valluru, R.
Author: Stangoulis, J.
Author: Sohu, V.S.
Author: Gurvinder Singh Mavi
Author: Vinod Kumar Mishra
Author: Balasubramaniam, A.
Author: Chatrath, R.
Author: Gupta, V.
Author: Gyanendra Pratap Singh
Author: Joshi, A.K
Year: 2018
ISSN: 2045-2322
URI: https://hdl.handle.net/10883/19626
Descriptors: Zinc
Descriptors: Spring wheat
Descriptors: Varieties
Abstract: Wheat is an important staple that acts as a primary source of dietary energy, protein, and essential micronutrients such as iron (Fe) and zinc (Zn) for the world?s population. Approximately two billion people suffer from micronutrient deficiency, thus breeders have crossed high Zn progenitors such as synthetic hexaploid wheat, T. dicoccum, T. spelta, and landraces to generate wheat varieties with competitive yield and enhanced grain Zn that are being adopted by farmers in South Asia. Here we report a genome-wide association study (GWAS) using the wheat Illumina iSelect 90 K Infinitum SNP array to characterize grain Zn concentrations in 330 bread wheat lines. Grain Zn phenotype of this HarvestPlus Association Mapping (HPAM) panel was evaluated across a range of environments in India and Mexico. GWAS analysis revealed 39 marker-trait associations for grain Zn. Two larger effect QTL regions were found on chromosomes 2 and 7. Candidate genes (among them zinc finger motif of transcription-factors and metal-ion binding genes) were associated with the QTL. The linked markers and associated candidate genes identified in this study are being validated in new biparental mapping populations for marker-assisted breeding.
Abstract: Wheat is an important staple that acts as a primary source of dietary energy, protein, and essential micronutrients such as iron (Fe) and zinc (Zn) for the world’s population. Approximately two billion people suffer from micronutrient deficiency, thus breeders have crossed high Zn progenitors such as synthetic hexaploid wheat, T. dicoccum, T. spelta, and landraces to generate wheat varieties with competitive yield and enhanced grain Zn that are being adopted by farmers in South Asia. Here we report a genome-wide association study (GWAS) using the wheat Illumina iSelect 90 K Infinitum SNP array to characterize grain Zn concentrations in 330 bread wheat lines. Grain Zn phenotype of this HarvestPlus Association Mapping (HPAM) panel was evaluated across a range of environments in India and Mexico. GWAS analysis revealed 39 marker-trait associations for grain Zn. Two larger effect QTL regions were found on chromosomes 2 and 7. Candidate genes (among them zinc finger motif of transcription-factors and metal-ion binding genes) were associated with the QTL. The linked markers and associated candidate genes identified in this study are being validated in new biparental mapping populations for marker-assisted breeding.
Language: English
Publisher: Nature Publishing Group
Copyright: CIMMYT manages Intellectual Assets as International Public Goods. The user is free to download, print, store and share this work. In case you want to translate or create any other derivative work and share or distribute such translation/derivative work, please contact CIMMYT-Knowledge-Center@cgiar.org indicating the work you want to use and the kind of use you intend; CIMMYT will contact you with the suitable license for that purpose.
Type: Article
Place: London
Journal issue: art. 13526
Journal: Scientific Reports
Journal volume: 8
DOI: 10.1038/s41598-018-31951-z
Keywords: Genome-Wide Association Studies
Keywords: Biofortification
Audicence: Researchers
Country of Focus: SOUTH ASIA
Country of Focus: INDIA
Country of Focus: MEXICO
Agrovoc: WHEAT
Agrovoc: HEXAPLOIDY
Agrovoc: ZINC
Agrovoc: GENETIC MARKERS


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  • Wheat
    Wheat - breeding, phytopathology, physiology, quality, biotech

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