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APA citation
Rajpal, V. R., Sharma, S., Kumar, A., Vaishnavi, S., Singh, A., Sehgal, D., Tiwari, M., Goel, S., & Raina, S. N. (2022). Mapping of SARS-COV-2 spike protein evolution during the first and second waves of COVID-19 infections in India. Future Virology, 17(8), 557-575. https://doi.org/10.2217/fvl-2021-0267
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The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials & methods: Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2020 to August 2021. Results: The study revealed 242 mutations corresponding to 207 sites. Fifty-one novel mutations emerged during the assessment period, including many with higher transmissibility and immune evasion functions. Highest number of mutations per spike protein also rose from 5 (first wave) to 13 (second wave). Conclusion: The study identified mutation-rich and no mutation regions in the spike protein. The conserved spike regions can be useful for designing future diagnostics, vaccines and therapeutics.
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Journal
Future Virology
Journal volume
17
Journal issue
8
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Place of Publication
United Kingdom
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Future Medicine Ltd.