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Sehgal, D., & Dreisigacker, S. (2019). Haplotypes-based genetic analysis: benefits and challenges. Vavilov Journal of Genetics and Breeding, 23(7), 803-808. https://doi.org/10.18699/vj19.37-o
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The increasing availability of Single Nucleotide Polymorphisms (SNPs) discovered by Next Generation Sequencing will enable a range of new genetic analyses in crops, which was not possible before. Concomitantly, researchers will face the challenge of handling large data sets at the whole-genome level. By grouping thousands of SNPs into a few hundred haplotype blocks, complexity of the data can be reduced with fewer statistical tests and a lower probability of spurious associations. Owing to the strong genome structure present in breeding lines of most crops, the deployment of haplotypes could be a powerful complement to improve efficiency of marker-assisted and genomic selection. This review describes in brief the commonly used approaches to construct haplotype blocks and some examples in animals and crops are cited where haplotype-based dissection of traits were proven beneficial. Some important considerations and facts while working with haplotypes in crops are reviewed at the end.
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Journal
Vavilov Journal of Genetics and Breeding
Journal volume
23
Journal issue
7
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Place of Publication
Novosibirsk (Russia)
Publisher
Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences