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Diaz-Badillo, A.

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Diaz-Badillo
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Diaz-Badillo, A.
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0000-0001-6267-3591

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    Data on a genome-wide association study of type 2 diabetes in a Maya population
    (Elsevier, 2020) Totomoch-Serra, A.; Domínguez-Cruz, M.G.; Muñoz, M.L.; García-Escalante, M.G.; Burgueño, J.; Diaz-Badillo, A.; Valadez-González, N.; Pinto-Escalantes, D.
    Maya communities have been shown to exhibit type 2 diabetes (T2D) with high prevalence compared with Mexican mestizo populations. Furthermore, some variants associated with the risk for T2D have been described. In this study, we describe the results of a pilot genome wide association study (GWAS) using 817,823 single nucleotide polymorphisms (SNPs) to identify candidate variants for replication in future studies. Herein, we present the GWAS study data, which were divided into three parts: first, 1289 ancestry informative markers (AIMs) were selected for Latino populations containing European, African, and Native American SNPs obtained from the literature; second, a GWAS hypothesis free to select candidate genes associated with T2D was performed, which identified 24 candidate genes; and third, 39 SNPs previously associated with T2D or related traits were replicated. This article is associated with the original article published in “Gene” under the title “Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population”.
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    A DNA Microarray-based assay to detect dual infection with two dengue virus serotypes
    (MDPI, 2014) Diaz-Badillo, A.; de Lourdes Muñoz, M.; Perez-Ramirez, G.; Altuzar, V.; Burgueño, J.; Mendoza-Alvarez, J.G.; Martínez-Muñoz, J.P.; Cisneros, A.; Navarrete-Espinosa, J.; Sanchez-Sinencio, F.A.
    Here; we have described and tested a microarray based-method for the screening of dengue virus (DENV) serotypes. This DNA microarray assay is specific and sensitive and can detect dual infections with two dengue virus serotypes and single-serotype infections. Other methodologies may underestimate samples containing more than one serotype. This technology can be used to discriminate between the four DENV serotypes. Single-stranded DNA targets were covalently attached to glass slides and hybridised with specific labelled probes. DENV isolates and dengue samples were used to evaluate microarray performance. Our results demonstrate that the probes hybridized specifically to DENV serotypes; with no detection of unspecific signals. This finding provides evidence that specific probes can effectively identify single and double infections in DENV samples
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